https://pjosr.com/index.php/pjosr/issue/feed Pakistan Journal of Scientific Research 2024-06-06T10:17:13+00:00 Prof. Dr. Muhammad Shoaib editor_in_chief@paas-pk.com Open Journal Systems <p>Pakistan Journal of Scientific Research (PJOSR) is a peer-reviewed, scientific and technical journal owned and published by the <strong>Pakistan Association for the Advancement of Science</strong>, Lahore, Pakistan<em>. PJOSR</em> publishes high-quality original scientific articles dealing with the use of analytic and quantitative tools for modelling, analysis, design and engineering management in Engineering and Technology. </p> https://pjosr.com/index.php/pjosr/article/view/1130 INTER-PROCESS COMMUNICATION AMONGST MICROSERVICES 2024-06-04T10:06:25+00:00 Maria Shehzadi mshahzadi@dummy.ot Nauman Riaz Chaudhry nauman.riaz@uog.edu.pk Abobakar Aslam aaslam@dummy.ot Reema Choudhary rchaudhry@dummy.ot <p><strong>The purpose of the study is to perform critical analysis on Inter-Process Communication (IPC) in the Microservice Architecture and to evaluate its impact on the basis of various non-business-related functionalities, such as effectiveness of performance, accessibility, adaptability, and complexity. There are various techniques for establishing IPC within Microservices, each with its own set of benefits and drawbacks. Throughout this research, IPC approaches are divided into two categories: synchronous and asynchronous. The Representational State Transfer Application Programming Interface (REST API) and google Remote Procedure Call (gRPC) are utilized in the synchronous kind, whereas Rabbit Message Queue (RabbitMQ) is utilized in the asynchronous type. A workload test was conducted across each model to get quantitative measurements on the Performance Efficiency and Accessibility of each technique, and a relatively similar functionality set was utilized to provide qualitative data on almost every other IPC method's adaptability and complexity. The research outcome shows if there is any standardized IPC solution that can be utilized in all scenarios.</strong></p> 2024-06-04T00:00:00+00:00 Copyright (c) 2024 https://pjosr.com/index.php/pjosr/cr https://pjosr.com/index.php/pjosr/article/view/1132 UNVEILING THE PATHOPHYSIOLOGICAL LANDSCAPE OF COVID-19: INSIGHTS FOR NOVEL THERAPEUTIC STRATEGIES 2024-06-06T10:17:13+00:00 Laiba Iqbal laibaaiqbal@gmail.com Dr. Naila Iqbal dr.nailaiqbal@gmail.com M. Milhan Afzal Khan milhankhan@uaf.edu.pk <p><strong>The ongoing COVID-19 epidemic has emphasised the critical need for a thorough understanding of the disease’s pathophysiology environment. This article explores the complex relationship between SARS-CoV-2, the virus responsible for COVID-19, and the human body, offering light on the underlying mechanisms that determine illness susceptibility, development, and severity. The genetic, immunological, and physiological aspects that contribute to the different clinical presentations of COVID-19 using a multidisciplinary approach have been discussed. This article aims to provide significant insights that pave the way for potential therapeutic options addressing the core pathophysiological processes by deciphering these complex pathways. As the global community attempts to combat the epi- demic, a fuller knowledge of COVID-19’s molecular complexities holds the prospect of new interventions that can effectively lessen its effects. In addition, a case study featuring Quantitative Poly- merase Chain Reaction (QPCR) amplification curves and Cycle Threshold (CT) values is shown to demonstrate the significance of making an accurate diagnosis. This diagnostic approach lets physicians to distinguish between positive and negative cases, assess viral load, and offer informed treatment recommendations. By combining QPCR results with clinical data, we can acquire a greater understanding of COVID-19’s progression and influence the development of novel therapy methods. This research aims to aid the global effort to eradicate COVID-19 by elucidating its pathophysiological intricacies and employing sophisticated diagnostic techniques such as (QPCR).</strong></p> 2024-06-06T00:00:00+00:00 Copyright (c) 2024 https://pjosr.com/index.php/pjosr/cr