Exploring the Synergistic Effects of Polyphenols and Gut Microbiota on Metabolic Health

Abstract

Dietary polyphenols are secondary metabolites and are one of the most abundant natural products present in the kingdom Plantae. They have high therapeutic potential and have been employed in the treatment of many diseases such as cardiovascular, neurodegenerative, obesity, diabetes, etc. According to much research, it has been seen that high consumption of these compounds impart many benefits to human health. However, it is difficult for the human digestive tract to digest these vital compounds, and they may accumulate in the large intestine where they are combined with the gut microbiota. The gut microbiota is a collection of different kinds of microorganisms such as bacteria present in the gut system. These microorganisms help in digesting polyphenolic compounds and impart various health benefits to humans. They along with phenolic compounds showed a variety of bioactivities such as anti-inflammatory, antidiabetic, antioxidant, etc. This review presents a comprehensive study of the mechanism of gut microbiota-polyphenolic interactions and their biological effects.