IN- VITRO ANTIUREASE ACTIVITY OF AQUEOUS-ETHANOL EXTRACT OF SOME MEDICINAL PLANTS

Abstract

Study was planned to evaluate urease inhibitory efficacy of aqueous-ethanol extract of medicinal plants including Mentha piperita, Violo odorata, Trachyspermum copticum, Metricarea chamomile and Foeniculum vulgare, traditionally used for management of gastrointestinal disorders. Phenol hypochlorite method was adopted to evaluate the urease inhibitory efficacy. The extracts were also phytochemically evaluated. The results showed that aqueous-ethanol extract of Mentha piperita, Violo odorata, Trachyspermum copticum, Metricarea chamomile and Foeniculum vulgare exhibited significant antiurease efficacy. The IC50 values of Mentha piperita, Metricarea hamomile, Foeniculum vulgare and Violo odorata extracts were 124±0.71, 119± 0.65, 119± 0.65 495±0.80 and 333±0.98 μg/ml respectively. Extract of Mentha piperita showed more antiurease potential in comparison to other plants extracts. Phytochemical screening of the extracts revealed the presence of alkaloids, tannins, saponins, flavonoids, flavones and sterol. The present study therefore, showed that the medicinal plants exhibit antiurease activity.