EFFECT OF MALATHION ON BLOOD BIOCHEMICAL PARAMETERS (UREA AND CREATININE) IN NILE TILAPIA (OREOCHROMIS NILOTICUS)

Abstract

The present study was conducted to evaluate the serological changes (urea and creatinine) in the kidneys of Nile tilapia (Oreochromis niloticus) after acute exposure to Malathion. Four groups of 15 fish were made each and categorized as; Group A: (control group) and Groups B, C and D (experimental groups). The LC50 of Malathion was 2µg/L at 96 hours of exposure in Nile tilapia. The fish were exposed to sub-lethal concentrations of 0.5, 1.0 and 1.5 µg/L to group B, C and D respectively. Blood samples were collected after 48, 72 and 96 hours of exposure to Malathion. Serum was separated and analyzed for levels of urea and creatinine that was significantly enhanced after acute exposure to Malathion at 48, 72 and 96 hours. Moreover, morphological and behavioral changes and mortality rates were also recorded. The results revealed that the pesticide (Malathion) has an adverse effect on kidneys. High levels of Malathion result in kidney damage and serological alterations in Nile tilapia.