A COMPARATIVE STUDY ON IMMUNOMODULATORY EFFECTS OF INDIGENOUS HERBAL DRUGS IN RABBITS

Abstract

Immunol®(syrup) (0.65ml/kg), Gen-Xing®(tablet) (7.2mg/kg) and MufarrehYakuuti®  (semi-solid) (87mg/kg) were administered orally at normal, 25% (0.82ml/kg, 9mg/kg and 107.5mg/kg) and 50% (0.98ml/kg, 10.8mg/kg and 129mg/kg) increased dose to healthy male rabbits for two weeks. Non-specific and Humoral immune responses were measured through
percent Neutrophil Adhesion assay and Haemagglutination Antibody assay against Sheep RBCs
respectively. Immunol revealed dose dependent response with maximum percent NA (92.58 ± 2.36 & 97.87±1.31) at 50% increased dose. Effect of drugs on Humoral Immune Response was significantly higher in terms of individual antibody titer and Geometric Mean Titer (GMT) as compared to control. However, Immunol® at 50 % and MufarrehYakuuti® at 25% increased doses showed highest GMT of 1024. GMTs decreased to 50% at 45th day of experiment with highest value of 64. The herbal
preparations enhanced the specific and non-specific immunity in rabbits under study. However,
Immunol was found to be the best and may be potential candidate for clinical use in future.