NUMERICAL APPROXIMATION OF DEGRADATION OF PLASMID DNA IN RAT PLASMA

Abstract

The scientific study revealed that the transport of plasmid Deoxyribonucleic acid (pDNA) towards the target sites played a vital role in creating a hurdle in gene delivery. In this study, the kinetic model of degradation of all the topoforms of pDNA namely super-coiled, open-circular and linear, have been discussed. The resulting system of ordinary differential equations (ODEs) has been numerically treated using various schemes, where the numerical results have been found to be in good agreement with the exact solutions. Further, it has been observed that, DTM gives more accurate results as compared with the results obtained by other numerical techniques.