PHYLOGENETIC STUDY OF SLC11A1 GENE IN DOMESTIC ANIMALS

Abstract

Solute carrier family 11-member a1 gene (SLC11a1) previously is a functional
member of metal ion-transport protein, earlier known as natural resistance-associated macrophage
protein 1 (NRAMP1). The cellular expression of this gene is restricted to phagocytic cells. The
function of this gene is to transport bivalent metal cations from the cytosol. The complex reaction of
Fenon and Haber-Weiss of this gene reacts toxic antimicrobial radicals against microorganisms. This
study investigates the evolutionary divergence of the SLC11a1 gene in domesticated farm animals.
SLC11a1 gene sequences of domesticated farm animals were retrieved from NCBI GenBank. The
results of this study revealed that there was substantial genetic variation in aligned sequences of the
SLC11a1 gene within selected species. One ns-mutation (Q312K) was found in this study which is
harmful. The phylogenetic trees showed some form of differentiation in the SLC11a1 gene sequence.
The information on SLC11a1 polymorphism might be used to associate with disease resistance of farm
animals in Pakistan.